Phenylarsine Oxide

Phenylarsine oxide is an organoarsenic compound. It inhibits insulin-induced protein phosphatase 1 (PP1) activity and glucose transporter 4 (Glut4) translocation in rat adipocytes when used at a concentration of 5 µM. Phenylarsine oxide completely inhibits insulin-induced PI3K activation and glucose transport in 3T3-L1 adipocytes when used at concentrations of 30 and 50 µM, respectively. It inhibits potassium chloride-induced exocytosis and induces mitochondrial depolarization in isolated rat brain synaptosomes. Phenylarsine oxide (0.3 and 1 mg/kg, i.p.) reduces LPS-induced neutrophil infiltration in bronchoalveolar lavage fluid (BALF) and carrageenan-induced paw edema in rats.Formal Name: oxophenyl-arsine. CAS Number: 637-03-6. Synonyms: NSC 42470. Molecular Formula: C6H5AsO. Formula Weight: 168.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: soluble. lambdamax: 221 nm. SMILES: O=[As]C1=CC=CC=C1. InChi Code: InChI=1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H. InChi Key: BQVCCPGCDUSGOE-UHFFFAOYSA-N.