PF-04937319 (hydrate)

PF-04937319 is an activator of glucokinase (EC50s = 174, 407, and 269 nM for the recombinant human, rat, and dog enzymes, respectively). It increases glucose-induced insulin secretion in isolated rat islets when used at concentrations of 4 and 12 µM. PF-04937319 (3-100 mg/kg) reduces postprandial plasma glucose levels in rats.Formal Name: N,N-dimethyl-5-[[2-methyl6-[[5-methyl-2-pyrazinyl)amino]carbonyl]-4-benzofuranyl]oxy]-2-pyrimidinecarboxamide, hydrate. Molecular Formula: C22H20N6O4 . XH2O. Formula Weight: 432.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM. SMILES: CN(C)C(C1=NC=C(OC2=C(C=C(C)O3)C3=CC(C(NC4=NC=C(C)N=C4)=O)=C2)C=N1)=O.O. InChi Code: InChI=1S/C22H20N6O4.H2O/c1-12-8-24-19(11-23-12)27-21(29)14-6-17-16(5-13(2)31-17)18(7-14)32-15-9-25-20(26-10-15)22(30)28(3)4,/h5-11H,1-4H3,(H,24,27,29),1H2. InChi Key: TZHWWOYEMHALRI-UHFFFAOYSA-N.