Penicillamine-d3

Penicillamine-d3 is intended for use as an internal standard for the quantification of D-penicillamine (Cay-23955) by GC- or LC-MS. Penicillamine is an orally bioavailable copper chelator and penicillin degradation product. It increases urinary and fecal copper excretion and decreases liver copper concentration in a rat model of copper overload when administered at 0.67 mmol/kg per day, but does not affect kidney, spleen, or brain copper levels. Penicillamine (100 mg/kg per day) dissolves copper-rich granules in hepatic lysosomes of Long-Evans cinnamon (LEC) rats, which spontaneously develop hepatic injury and acute hepatitis and have a mutation homologous to that of the human Wilson disease gene. Penicillamine has anticonvulsant and proconvulsant effects in mice when administered at 0.5 and 250 mg/kg, respectively, which are blocked by the nitric oxide synthase (NOS) inhibitors L-NAME (Cay-80210) and 7-nitroindazole (Cay-81340). Formulations containing penicillamine have been used to treat Wilson disease, cystinuria, and active rheumatoid arthritis.Formal Name: 3-mercapto-D-valine-4,4,4-d3. CAS Number: 2925655-01-0. Synonyms: D-Penicillamine-d3, beta-Thiovaline-d3. Molecular Formula: C5H8D3NO2S. Formula Weight: 152.2. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Water: soluble. SMILES: CC(C([2H])([2H])[2H])(S)[C@@H](N)C(O)=O. InChi Code: InChI=1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1/i1D3/t3-,5?. InChi Key: VVNCNSJFMMFHPL-JCBLVLITSA-N.