Peiminine

Peiminine is an alkaloid that has been found in Fritillaria and has diverse biological activities. It increases protein levels of the autophagy marker LC3B-II and induces cell death in HCT116 colorectal carcinoma cells in a concentration-dependent manner. Peiminine (3 mg/kg every other day) reduces tumor growth in an HCT116 mouse xenograft model. It has antitussive effects in a mouse cough model induced by ammonia liquor when administered at a dose of 3 mg/kg. Peiminine (5 mg/kg) reduces dermal and epidermal thickness, inhibits dermal infiltration of eosinophils and mast cells, and decreases serum levels of IgE, IL-4, and TNF-alpha in a mouse model of atopic dermatitis induced by dinitrochlorobenzene (DNCB).Formal Name: (5alpha)-3beta,20-dihydroxy-cevan-6-one. CAS Number: 18059-10-4. Synonyms: Verticinone. Molecular Formula: C27H43NO3. Formula Weight: 429.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMSO: 15mg/mL, DMSO:PBS (pH 7.2) (1:30): 0.03mg/mL, Ethanol: 10mg/mL. SMILES: C[C@H]1CC[C@@]2([H])[C@](O)(C)[C@@]3([H])CC[C@@]4([H])[C@]5([H])CC([C@]6([H])[C@@](CC[C@H](O)C6)(C)[C@@]5([H])C[C@@]4([H])[C@]3([H])CN2C1)=O. InChi Code: InChI=1S/C27H43NO3/c1-15-4-7-25-27(3,31)21-6-5-17-18(20(21)14-28(25)13-15)11-22-19(17)12-24(30)23-10-16(29)8-9-26(22,23)2/h15-23,25,29,31H,4-14H2,1-3H3/t15-,16-,17+,18+,19-,20-,21-,22-,23+,25-,26+,27-/m0/s1. InChi Key: IQDIERHFZVCNRZ-YUYPDVIUSA-N. Origin: Plant/Fritillaria thun-bergli.