PCI 27483

PCI 27483 is a small molecule inhibitor of activated coagulation factor VIIa with antithrombotic effects in a baboon model of arterial thrombosis. It also inhibits the growth of BxPC3 xenografts by 42 and 85% at doses of 60 and 90 mg/kg, respectively.Formal Name: N-[2-[5-[6-(aminoiminomethyl)-1H-benzimidazol-2-yl]-5'-(aminosulfonyl)-2',6-dihydroxy[1,1'-biphenyl]-3-yl]acetyl]-L-aspartic acid. CAS Number: 871266-63-6. Molecular Formula: C26H24N6O9S. Formula Weight: 596.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 230, 307, 340 nm. SMILES: NS(C1=CC(C2=CC(CC(N[C@H](C(O)=O)CC(O)=O)=O)=CC(C3=NC(C=CC(C(N)=N)=C4)=C4N3)=C2O)=C(O)C=C1)(=O)=O. InChi Code: InChI=1S/C26H24N6O9S/c27-24(28)12-1-3-17-18(8-12)32-25(31-17)16-6-11(7-21(34)30-19(26(38)39)10-22(35)36)5-15(23(16)37)14-9-13(42(29,40)41)2-4-20(14)33/h1-6,8-9,19,33,37H,7,10H2,(H3,27,28)(H,30,34)(H,31,32)(H,35,36)(H,38,39)(H2,29,40,41)/t19-/m0/s1. InChi Key: WDJHHCAKBRKCLW-IBGZPJMESA-N.