PBD-150

PBD-150 is an inhibitor of glutaminyl cyclase (Ki = 0.49 µM for the human enzyme). It inhibits the formation of the pyroglutamic acid-containing amyloid-beta (Abeta) peptides pGlu-Abeta (3-40) and pGlu-Abeta (3-42) in HEK293 cells expressing human glutaminyl cyclase and human amyloid precursor protein (APP) with an N-terminal deletion of the first two amino acids.Formal Name: N-(3,4-dimethoxyphenyl)-N'-[3-(1H-imidazol-1-yl)propyl]-thiourea. CAS Number: 790663-33-1. Molecular Formula: C15H20N4O2S. Formula Weight: 320.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml. lambdamax: 249 nm. SMILES: S=C(NCCCN1C=NC=C1)NC2=CC(OC)=C(OC)C=C2. InChi Code: InChI=1S/C15H20N4O2S/c1-20-13-5-4-12(10-14(13)21-2)18-15(22)17-6-3-8-19-9-7-16-11-19/h4-5,7,9-11H,3,6,8H2,1-2H3,(H2,17,18,22). InChi Key: FZQXMGLQANXZRP-UHFFFAOYSA-N.