Panaxatriol

Panaxatriol is a sapogenin that has been found in P. ginseng and has diverse biological activities, including antiproliferative, cardioprotective, and antidiabetic properties. It inhibits the proliferation of DU15 prostate cancer cells (IC50 = 30 µM) and induces apoptosis by increasing production of reactive oxygen species (ROS) and decreasing the mitochondrial membrane potential. Panaxatriol (5 mg/kg) reduces ischemia and reperfusion-induced myocardial dysfunction, increases left ventricular developed pressure (LVDevP) and glutathione (GSH) levels, and decreases cardiac lactate dehydrogenase (LDH), creatine kinase (CK), and malondialdehyde (MDA) levels in rats when administered for seven consecutive days prior to injury. Dietary administration of panaxatriol (0.2% for 6 weeks) decreases fasting blood glucose levels in KKAy insulin-resistant mice.Formal Name: (3beta,6beta,12beta,20R)-20,25-epoxy-dammarane-3,6,12-triol. CAS Number: 32791-84-7. Synonyms: NSC 308880. Molecular Formula: C30H52O4. Formula Weight: 476.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMSO: 3mg/mL, Ethanol: 10mg/mL, Ethanol:PBS (pH 7.2) (1:5): 0.16mg/mL. SMILES: CC1(C)[C@@H](O)CC[C@@]2(C)[C@@]1([H])[C@H](O)C[C@]3(C)[C@]2([H])C[C@@H](O)[C@@]4([H])[C@@]3(C)CC[C@]4([H])[C@]5(C)OC(C)(C)CCC5. InChi Code: InChI=1S/C30H52O4/c1-25(2)12-9-13-30(8,34-25)18-10-15-28(6)23(18)19(31)16-21-27(5)14-11-22(33)26(3,4)24(27)20(32)17-29(21,28)7/h18-24,31-33H,9-17H2,1-8H3/t18-,19+,20+,21+,22-,23-,24-,27+,28+,29+,30+/m0/s1. InChi Key: QFJUYMMIBFBOJY-UXZRXANASA-N. Origin: Plant/Panax ginseng.