Palmatine (chloride)

Palmatine is an alkaloid that has been found in C. rhizoma and has diverse biological activities. It inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE, IC50s = 0.51 and 6.84 µM, respectively). Palmatine (20, 40, and 80 µM) reduces Zika virus infection of Vero cells in a concentration-dependent manner. In vivo, palmatine (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and IL-10, IL-1beta, IL-6, and TNF-alpha levels, as well as protects mucosal integrity in a mouse model of colitis induced by dextran sulfate (DSS, Cay-23250). It reduces stomach ulcer area in a rat model of acetic acid-induced gastric ulcers. Palmatine (10 and 20 mg/kg) reduces the number of small intestine and colon tumors in the ApcMin+/- mouse model of multiple intestinal neoplasia.Formal Name: 5,6-dihydro-2,3,9,10-tetramethoxy-dibenzo[a,g]quinolizinium, monochloride. CAS Number: 10605-02-4. Molecular Formula: C21H22NO4 . Cl. Formula Weight: 387.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 229, 267, 350, 433 nm. SMILES: COC1=CC=C2C(C=[N+](CCC3=CC(OC)=C(OC)C=C34)C4=C2)=C1OC.[Cl-]. InChi Code: InChI=1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4,/h5-6,9-12H,7-8H2,1-4H3,1H/q+1,/p-1. InChi Key: RLQYRXCUPVKSAW-UHFFFAOYSA-M. Origin: Plant/Fibraurea recisa.