Pachybasin

Pachybasin is an anthraquinone fungal metabolite. It inhibits the growth of E. coli, S. aureus, B. subtilis, and M. luteus bacteria (MICs = 64, 32, 64, and 64 µg/ml, respectively) and C. albicans, S. cerevisiae, A. niger, A. flavus, and F. oxysporum fungi (MICs = 64, 64, 64, 64, and 16 µg/ml, respectively). It also induces germ tube malformation in B. graminis fungi. Pachybasin induces developmental retardation and notochord distortions and increases mortality in zebrafish embryos when used at concentrations ranging from 1 to 100 µM.Formal Name: 1-hydroxy-3-methyl-9,10-anthracenedione. CAS Number: 2549-78-2. Synonyms: 1-Hydroxy-3-methylanthraquinone. Molecular Formula: C15H10O3. Formula Weight: 238.2. Purity: >70%. Formulation: (Request formulation change), A solid. Solubility: Dichloromethane: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C1C2=C(C(O)=CC(C)=C2)C(C3=CC=CC=C31)=O. InChi Code: InChI=1S/C15H10O3/c1-8-6-11-13(12(16)7-8)15(18)10-5-3-2-4-9(10)14(11)17/h2-7,16H,1H3. InChi Key: AFHWNNJNTNLCQF-UHFFFAOYSA-N. Origin: Fungus/Unidentified sp..