p,p'-DDT

p,p'-DDT is an organochlorine pesticide that induces 94.2% mortality of malaria mosquito (A. quadrimaculatus) fourth-instar larvae and 100% mortality of A. aegypti larvae when used at concentrations of 0.01 and 0.05 ppm, respectively. It increases secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles when used at concentrations of greater than or equal to 4 ng/ml and increases apoptosis in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 80 to 150 µg/ml. p,p'-DDT (5 nmol/kg, i.p.) increases tumor growth in a DLD1 colorectal adenocarcinoma nude mouse xenograft model. It induces 100% mortality of C. auratus (goldfish) at 0.25 ppm and is lethal to rats but not hamsters (LD50s = 120 and ~5,000 mg/kg, respectively). p,p'-DDT is a persistent organic pollutant (POP) and is elevated in the sera of pregnant women in malaria-endemic regions of South Africa.Formal Name: 1,1'-(2,2,2-trichloroethylidene)bis[4-chloro-benzene]. CAS Number: 50-29-3. Synonyms: 4,4'-DDT, 4,4'-Dichlorodiphenyltrichloroethane, p,p'-Dichlorodiphenyltrichloroethane, Dicophaner, NSC 8939. Molecular Formula: C14H9Cl5. Formula Weight: 354.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, Methanol: Heated. SMILES: ClC1=CC=C(C(C(Cl)(Cl)Cl)C2=CC=C(Cl)C=C2)C=C1. InChi Code: InChI=1S/C14H9Cl5/c15-11-5-1-9(2-6-11)13(14(17,18)19)10-3-7-12(16)8-4-10/h1-8,13H. InChi Key: YVGGHNCTFXOJCH-UHFFFAOYSA-N.