(+)-Oxypeucedanin hydrate

(+)-Oxypeucedanin hydrate is a furanocoumarin that has been found in A. japonica and has diverse biological activities. It is active against the Gram-positive bacteria B. cereus, S. aureus, and S. faecalis (MICs = 9.76-78.12 µg/ml), the Gram-negative bacteria E. coli, S. dysenteriae, P. aeruginosa, K. pneumoniae, and S. typhi (MICs = 39.06-625 µg/ml), and the fungi C. albicans and M. audouinii (MIC = 39.06 µg/ml for both). (+)-Oxypeucedanin hydrate inhibits proliferation of human MK-1 gastric and HeLa cervical cancer cells, as well as murine B16/F10 melanoma cells (EC50s = 47.2, 80.3, and 42 µg/ml, respectively). It also inhibits proliferation of sensitive and multidrug-resistant murine L5178Y lymphoma cells (IC50s = 41.96 and 60.58 µM, respectively).Formal Name: 4-[(2R)-2,3-dihydroxy-3-methylbutoxy]-7H-furo[3,2-g][1]benzopyran-7-one. CAS Number: 2643-85-8. Synonyms: (+)-Aviprin, Prangol, Prangolarin hydrate. Molecular Formula: C16H16O6. Formula Weight: 304.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml, Ethanol: 5 mg/ml. lambdamax: 222, 251, 260, 269, 310 nm. SMILES: CC(C)(O)[C@H](O)COC1=C(C=CO2)C2=CC(O3)=C1C=CC3=O. InChi Code: InChI=1S/C16H16O6/c1-16(2,19)13(17)8-21-15-9-3-4-14(18)22-12(9)7-11-10(15)5-6-20-11/h3-7,13,17,19H,8H2,1-2H3/t13-/m1/s1. InChi Key: PEWFWDOPJISUOK-CYBMUJFWSA-N. Origin: Plant/Angelica dahurica.