Oxymatrine

Oxymatrine is a natural alkaloid isolated from the root of S. flavescens, an herb used in traditional Chinese herbal medicine. It has antiviral properties, inhibiting the replication of hepatitis B alone and in combination with lamivudine. Oxymatrine also prevents fibrosis in a number of organs including liver, at least in part by interfering with TGF-beta signaling. This compound also induces apoptosis in certain cancer cells and ameliorates inflammation by impairing the translocation of nuclear factors-kappaB.Formal Name: (4R,7aS,13aR,13bR,13cS)-dodecahydro-4-oxide-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one. CAS Number: 16837-52-8. Synonyms: Matrine 1-oxide. Molecular Formula: C15H24N2O2. Formula Weight: 264.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 33.3 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C1N2[C@@](CCC1)([H])[C@]3([H])[C@@]4([H])[N+](CCC[C@@]4([H])C2)([O-])CCC3. InChi Code: InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-,17?/m0/s1. InChi Key: XVPBINOPNYFXID-LHDUFFHYSA-N.