Oxy-16

Naturally occurring oxysterols are products of cholesterol oxidation that can stimulate the hedgehog (Hh) signaling pathway in target cells associated with cardiovascular disease and with bone formation. Depending on the target cell, activation of Hh signaling can modulate inflammatory responses to additional atherogenic factors such as lesion-producing macrophages or enable osteoblast differentiation. Oxy-16 is a synthetic oxysterol compound that may function as an antagonist of hedgehog activity. Published data regarding its efficacy remains forthcoming.Formal Name: cholest-5-ene-3b,20,22R-triol. CAS Number: 596-94-1. Synonyms: 20(R),22(R)-dihydroxy Cholesterol. Molecular Formula: C27H46O3. Formula Weight: 418.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1.5 mg/ml, DMSO: 2 mg/ml, Ethanol: 10 mg/ml. SMILES: O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])C2CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@](C)(O)[C@H](O)CCC(C)C. InChi Code: InChI=1S/C27H46O3/c1-17(2)6-11-24(29)27(5,30)23-10-9-21-20-8-7-18-16-19(28)12-14-25(18,3)22(20)13-15-26(21,23)4/h7,17,19-24,28-30H,6,8-16H2,1-5H3/t19-,20-,21-,22?,23-,24+,25-,26-,27+/m0/s1. InChi Key: ISBSSBGEYIBVTO-RCXKVKFCSA-N.