Oxibendazole

Oxibendazole is a benzimidazole anthelmintic. It inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin and inhibits mammalian tubulin polymerization (IC50s = 0.3 and 2.2 µM, respectively). When used in combination with the anthelmintic niclosamide (Cay-10649), oxibendazole (15 mg/kg) reduces fecal worm egg counts in dogs and cats by greater than 90% for the nematodes T. canis, T. vulpis, A. caninum, and T. leonine. It also reduces fecal egg counts of strongyles in horses when administered at a dose of 10 mg/kg per day. Formulations containing oxibendazole have been used in the prevention and treatment of parasitic worm infections in dogs and the treatment of parasitic worm infections in horses.Formal Name: N-(6-propoxy-1H-benzimidazol-2-yl)-carbamic acid, methyl ester. CAS Number: 20559-55-1. Molecular Formula: C12H15N3O3. Formula Weight: 249.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 3 mg/ml, Ethanol: Partially soluble, PBS (pH 7.2): Partially soluble. lambdamax: 247, 296 nm. SMILES: CCCOC1=CC=C2C(N=C(NC(OC)=O)N2)=C1. InChi Code: InChI=1S/C12H15N3O3/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16). InChi Key: RAOCRURYZCVHMG-UHFFFAOYSA-N.