Orphenadrine (hydrochloride)

Orphenadrine is a muscarinic acetylcholine receptor (mAChR) antagonist (Kds = 48, 213, 120, 170, and 129 nM for M1-M5 receptors, respectively). Orphenadrine (2-5 mg/kg, i.v.) decreases muscle activity induced by the mAChR agonist oxotremorine in rabbits. It is also an NMDA receptor antagonist with a Ki value of 6 µM in a radioligand binding assay in human postmortem frontal cortex and an IC50 value of 16.2 µM for inhibiting steady state currents in cultured superior colliculus neurons. Formulations containing orphenadrine have been used in the treatment of acute painful musculoskeletal conditions, including muscle spasms.Formal Name: N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-ethanamine, monohydrochloride. CAS Number: 341-69-5. Synonyms: NSC 82357. Molecular Formula: C18H23NO . HCl. Formula Weight: 305.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 33 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: CN(C)CCOC(C1=CC=CC=C1C)C2=CC=CC=C2.Cl. InChi Code: InChI=1S/C18H23NO.ClH/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16,/h4-12,18H,13-14H2,1-3H3,1H. InChi Key: UQZKYYIKWZOKKD-UHFFFAOYSA-N.