Oroxylin A

Oroxylin A is a flavonoid that has been found in S. radix and has diverse biological activities. It inhibits decreases in cell viability and increases in nitric oxide (NO) production induced by polyinosinic-polycytidylic acid (poly(I:C)) in RAW 264.7 macrophages when used at concentrations ranging from 5 to 25 µM. Oroxylin A (10-50 µM) also inhibits poly(I:C)-induced increases in IL-1alpha, IL-1beta, GM-CSF, IL-6, IL-10, monocyte chemoattractant protein-1 (MCP-1), and TNF-alpha production in RAW 264.7 cells. Oroxylin A (10 and 20 µM) inhibits hypoxia-induced migration and invasion of MCF-7, DU145, and HepG2 cells in wound healing and cell invasion assays, respectively. It is an inhibitor of the UDP-glucuronosyltransferase (UGT) isoform UGT1A1 (IC50 = 9.14 µM) and P-glycoprotein (IC50 = 78.3 µM). Oroxylin A increases the cytotoxicity of the P-glycoprotein substrate paraquat in MDR1-MDCKII cells and paclitaxel (Cay-10461) in MX-1 and MX-1/T cells.Formal Name: 5,7-dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one. CAS Number: 480-11-5. Synonyms: 6-Methoxybaicalein. Molecular Formula: C16H12O5. Formula Weight: 284.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml. lambdamax: 215, 273, 321 nm. SMILES: O=C1C2=C(O)C(OC)=C(O)C=C2OC(C3=CC=CC=C3)=C1. InChi Code: InChI=1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3. InChi Key: LKOJGSWUMISDOF-UHFFFAOYSA-N. Origin: Plant/Oroxylum indicum.