Ornidazole

Ornidazole is an orally bioavailable 5-nitroimidazole derivative with antibacterial and antiprotozoal activities. Ornidazole inhibits the growth of clinical isolates of B. fragilis (MICs = 0.5-5 µM) and various anaerobic bacteria when used at concentrations ranging from less than 0.1 to 3.2 µg/ml. It also inhibits the growth of Giardia isolates (IC50s = 0.01-0.47 µg/ml). Oral administration of ornidazole reduces T. vaginalis and T. foetus infection in mice and E. histolytica infection in rats with curative dose (CD50) values of 37, 3, and 10 mg/kg, respectively. Ornidazole (400 mg/kg per day) induces infertility in male rats within 7 days and inhibits spermatozoa binding to rat oocyte zona pellucida.Formal Name: alpha-(chloromethyl)-2-methyl-5-nitro-1H-imidazole-1-ethanol. CAS Number: 16773-42-5. Synonyms: NSC 95075, (±)-Ornidazole, Ro 7-0207. Molecular Formula: C7H10ClN3O3. Formula Weight: 219.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 14 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 3 mg/ml. lambdamax: 312 nm. SMILES: OC(CCl)CN1C(C)=NC=C1[N+]([O-])=O. InChi Code: InChI=1S/C7H10ClN3O3/c1-5-9-3-7(11(13)14)10(5)4-6(12)2-8/h3,6,12H,2,4H2,1H3. InChi Key: IPWKIXLWTCNBKN-UHFFFAOYSA-N.