Orfamide A

Description: Orfamide A, a lipopeptide biosurfactant isolated from P. protegens, exhibits multifaceted bioactivity. With an LC50 of 34.5 µg/ml, it significantly increases mortality in adult green peach aphids. Additionally, at a concentration of 50 µM, Orfamide A inhibits appressoria formation in M. oryzae isolates and decreases the prevalence of sporulating blast lesions in M. oryzae-infected plants. Furthermore, it demonstrates efficacy against T. b. brucei, with an IC50 value of 6 µM. Target: Others. Smiles: CCCCCCCCCCC[C@H](O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]1[C@@H](C)OC(=O)[C@@H](NC(=O)[C@@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC1=O)[C@@H](C)CC)C(C)C