ONO-2920632

A K2P2.1/TREK-1 and K2P10.1/TREK-2 activator, induces K2P2.1/TREK-1 and K2P10.1/TREK-2 activity in thallium flux assays using CHO cells expressing K2P2.1/TREK-1 and HEK293 cells expressing K2P10.1/TREK-2 (EC50s = 2.8 and 0.3 µM, respectively), selective for K2P2.1/TREK-1 and K2P10.1/TREK-2 over 72 other ion channels, GPCRs, transporters, and nuclear hormones at 10 µM, prevents acetic acid-induced writhing in mice at 3 mg/kg. Formulation: A neat solid. InChI: InChI=1S/C15H10F4N4O2/c16-12-5-11(25-15(17,18)19)3-1-9(12)6-20-14(24)10-2-4-13-21-8-22-23(13)7-10/h1-5,7-8H,6H2,(H,20,24). InChIKey: KDTQFQYXTWVBCC-UHFFFAOYSA-N. SMILES: O=C(C1=CN2N=CN=C2C=C1)NCC3=C(F)C=C(C=C3)OC(F)(F)F