Olumacostat Glasaretil

Olumacostat glasaretil is an inhibitor of acetyl-CoA carboxylase (ACC). It increases the ratio of acetyl-CoA to free CoA in hamster ear sebaceous glands when applied topically at a concentration of 6% (w/w). Olumacostat glasaretil (0.3, 1, or 3 µM) inhibits triacylglycerol formation induced by T0901317 (Cay-71810) and insulin in primary human sebocytes. It decreases hamster ear sebaceous gland lipid area when applied topically at a concentration of 6% (w/w) twice per day. InChI: InChI=1S/C26H43NO7/c1-4-6-7-8-9-10-11-12-13-14-15-16-19-32-25-18-17-22(34-25)26(30)33-21-23(28)27(3)20-24(29)31-5-2/h17-18H,4-16,19-21H2,1-3H3 InChIKey: FYJLDICZGDFWKP-UHFFFAOYSA-N SMILES: O=C(C1=CC=C(OCCCCCCCCCCCCCC)O1)OCC(N(CC(OCC)=O)C)=O