Oleocanthal

Oleocanthal is a secoiridoid polyphenol that has been found in O. europaea and has diverse biological activities. It inhibits the proliferation of CWR-R1ca, PC3, PC-3M, and DU145 prostate cancer cells (IC50s = 3.59, 0.64, 1.03, and 5.35 µM, respectively). Oleocanthal inhibits the growth of L. major promastigotes and amastigotes in vitro (IC50s = 18.7 and 87 µg/ml, respectively) and reduces lymph node parasite burden in a mouse model of leishmaniasis when administered at a dose of 5 mg/kg. Oleocanthal (5 mg/kg) reduces hippocampal amyloid-beta (Abeta) levels in a TgSwDI transgenic mouse model of Alzheimer's disease. Intragastric administration of oleocanthal (5 mg/kg) decreases serum IL-6 and TNF-alpha levels and reduces lung cell apoptosis in a chicken model of LPS-induced acute lung injury.Formal Name: (3S,4E)-4-formyl-3-(2-oxoethyl)-4-hexenoic acid, 2-(4-hydroxyphenyl)ethyl ester. CAS Number: 289030-99-5. Synonyms: (-)-Oleocanthal. Molecular Formula: C17H20O5. Formula Weight: 304.3. Purity: >95%. Formulation: (Request formulation change), A neat oil. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: OC1=CC=C(CCOC(C[C@H](CC([H])=O)/C(C([H])=O)=C\C)=O)C=C1. InChi Code: InChI=1S/C17H20O5/c1-2-14(12-19)15(7-9-18)11-17(21)22-10-8-13-3-5-16(20)6-4-13/h2-6,9,12,15,20H,7-8,10-11H2,1H3/b14-2-/t15-/m0/s1. InChi Key: VPOVFCBNUOUZGG-VAKDEWRISA-N. Origin: Plant/Olea europaea.