Oleanolic Acid Acetate

Oleanolic acid acetate is a triterpene that has been found in the root bark of M. macrophylla and has diverse biological activities. It is active against P. gingivalis (MIC = 39 µg/ml). Oleanolic acid acetate (5-50 µM) induces apoptosis in and reduces viability of HCT116 colon carcinoma cells. It induces apoptosis in human umbilical vein endothelial cells (HUVECs) in vitro and inhibits capillary vessel formation in a Matrigel(TM) plug assay in mice. Oleanolic acid acetate (2, 10, and 50 mg/kg) reduces the number of skin lesions, epidermal thickness and immune cell infiltration, and serum IgE, IgG2a, and histamine levels in a mouse model of atopic dermatitis.Formal Name: 3beta-(acetyloxy)-olean-12-en-28-oic acid. CAS Number: 4339-72-4. Synonyms: 3-Acetyloleanolic Acid. Molecular Formula: C32H50O4. Formula Weight: 498.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 0.14 mg/ml. SMILES: CC1(C)CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](OC(C)=O)CC[C@]5(C)[C@@]4([H])CC=C3[C@]2([H])C1. InChi Code: InChI=1S/C32H50O4/c1-20(33)36-25-12-13-29(6)23(28(25,4)5)11-14-31(8)24(29)10-9-21-22-19-27(2,3)15-17-32(22,26(34)35)18-16-30(21,31)7/h9,22-25H,10-19H2,1-8H3,(H,34,35)/t22-,23-,24+,25-,29-,30+,31+,32-/m0/s1. InChi Key: RIXNFYQZWDGQAE-DFHVBEEKSA-N. Origin: Plant/Glycyrrhizae radix et rhizoma.