Olanzapine

Olanzapine is an atypical antipsychotic that binds to dopamine D1, D2, and D4 receptors (Kis = 31, 11, and 27 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C, and 5-HT3 (Kis = 4, 11, and 57 nM, respectively). It also binds to M1 muscarinic acetylcholine, alpha1-adrenergic, and histamine H1 receptors (Kis = 2, 19, and 7 nM, respectively). Olanzapine (0.5 mg/kg, i.p.) decreases immobility time in the forced swim test in non-stressed and prenatally-stressed rats, indicating antidepressant-like activity. It also decreases the number of avoidances made in the conditioned avoidance response test in rats when administered at doses of 0.5 and 1 mg/kg. Formulations containing olanzapine have been used in the treatment of schizophrenia and bipolar disorder.Formal Name: 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine. CAS Number: 132539-06-1. Synonyms: LY170053. Molecular Formula: C17H20N4S. Formula Weight: 312.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 16 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 226, 272 nm. SMILES: CN(CC1)CCN1C2=NC3=CC=CC=C3NC4=C2C=C(C)S4. InChi Code: InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3. InChi Key: KVWDHTXUZHCGIO-UHFFFAOYSA-N.