o,p'-DDE

o,p'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT. It accumulates in smallmouth buffalo, channel catfish, and largemouth bass as well as sediment in the Huntsville Spring Branch-Indian Creek tributary system surrounding a DDT manufacturing plant where it is considered a persistent organic pollutant (POP). o,p'-DDE inhibits estrogen binding to rainbow trout estrogen receptors (rtERs) with an IC50 value of 3.2 µM. It induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles. In ovo exposure to o,p'-DDE increases degeneration of ovarian follicles and reduces testicular size in Japanese medaka (O. latipes).Formal Name: 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethenyl]-benzene. CAS Number: 3424-82-6. Synonyms: 2,4'-DDE, o,p'-Dichlorodiphenyldichloroethylene, NSC 59908. Molecular Formula: C14H8Cl4. Formula Weight: 318.0. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Heated, Methanol: Slightly Soluble. SMILES: ClC1=CC=C(/C(C2=CC=CC=C2Cl)=C(Cl)\Cl)C=C1. InChi Code: InChI=1S/C14H8Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8H. InChi Key: ZDYJWDIWLRZXDB-UHFFFAOYSA-N.