NSC 102533

A P2X7 receptor antagonist, inhibits ATP-induced dye uptake in HEK293 cells expressing human purinergic P2X7 receptors (IC50 = 22.4 nM), inhibits common lancehead (B. atrox) venom proteolysis in a concentration-dependent manner, inhibits ATP-induced IL-1ß secretion in human THP-1 monocytes and primary mouse peritoneal macrophages (IC50s = 9.8 and 11.2 nM, respectively), inhibits common lancehead (B. atrox) and jararaca (B. jararaca) venom-induced skin hemorrhage in mice when intradermally administered at 3 mg/kg, inhibits carrageenan-induced paw edema in mice at 0.01 to 1 mg/kg. Formulation: A solid. InChI: InChI=1S/C16H10O3/c17-14-11-8-4-5-9-12(11)15(18)16(19)13(14)10-6-2-1-3-7-10/h1-9,19H. InChIKey: KUKDVSFMDRAXML-UHFFFAOYSA-N. SMILES: O=C1C(O)=C(C(C2=C1C=CC=C2)=O)C3=CC=CC=C3