NS 5806

NS 5806 is an activator of the calcium-independent transient outward potassium current (Ito). It increases Kv4.3-mediated Ito current amplitudes (EC50 = 5.3 µM), as well as slows Ito current decay in a manner dependent on potassium channel interaction protein 2 (KChIP2), in CHO-K1 cells expressing human Kv4.3. NS 5806 increases Ito currents in isolated rabbit ventricular myocytes (EC50 = 1.6 µM). It reverses rapid pacing-induced decreases in Ito current recovery and restores the spike-and-dome morphology of the epicardial action potential in ventricular wedge preparations isolated from a dog heart in a model of heart failure.Formal Name: N-[3,5-bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]-urea. CAS Number: 426834-69-7. Molecular Formula: C16H8Br2F6N6O. Formula Weight: 574.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 50 mg/ml, Ethanol: 25 mg/ml. lambdamax: 245 nm. SMILES: O=C(NC1=C(C2=NN=NN2)C=C(Br)C=C1Br)NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3. InChi Code: InChI=1S/C16H8Br2F6N6O/c17-8-4-10(13-27-29-30-28-13)12(11(18)5-8)26-14(31)25-9-2-6(15(19,20)21)1-7(3-9)16(22,23)24/h1-5H,(H2,25,26,31)(H,27,28,29,30). InChi Key: UZWJWROOLOOCPQ-UHFFFAOYSA-N.