Notoginsenoside R1

Notoginsenoside R1 is a saponin that has been found in P. notoginseng and has diverse biological activities, including cardioprotective, neuroprotective, and anti-inflammatory properties. It decreases serum total cholesterol, triacylglycerol, and oxidized LDL (oxLDL) levels, as well as reduces atherosclerotic lesion area and lipid deposition in the aortic root of ApoE-/- mice fed a Western diet when administered at a dose of 25 mg/kg per day for eight weeks. Notoginsenoside R1 (100 mg/kg) inhibits apoptosis of hippocampal neurons and reduces infarct size in a rat model of cerebral ischemia-reperfusion injury induced by bilateral common carotid artery occlusion. It decreases colonic NF-?B and myeloperoxidase (MPO) activities and TNF-alpha and IL-6 levels, as well as reduces colonic shortening, tissue damage, and inflammatory cell infiltration in a mouse model of colitis induced by dextran sulfate sodium (DSS, Cay-23250) when administered at a dose of 25 mg/kg per day for seven days.Formal Name: (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-beta-D-xylopyranosyl-beta-D-glucopyranoside. CAS Number: 80418-24-2. Synonyms: Sanchinoside R1. Molecular Formula: C47H80O18. Formula Weight: 933.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.1 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)(C)CC/C=C(C)/C)(C)[C@]4(C)C[C@H](O[C@H]5[C@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)CO6)[C@@H](O)[C@H](O)[C@@H](CO)O5)[C@]7([H])[C@@](CC[C@H](O)C7(C)C)(C)[C@@]4([H])C1. InChi Code: InChI=1S/C47H80O18/c1-21(2)10-9-13-47(8,65-41-37(59)34(56)32(54)26(18-48)62-41)22-11-15-45(6)30(22)23(50)16-28-44(5)14-12-29(52)43(3,4)39(44)25(17-46(28,45)7)61-42-38(35(57)33(55)27(19-49)63-42)64-40-36(58)31(53)24(51)20-60-40/h10,22-42,48-59H,9,11-20H2,1-8H3/t22-,23+,24+,25-,26+,27+,28+,29-,30-,31-,32+,33+,34-,35-,36+,37+,38+,39-,40-,41-,42+,44+,45+,46+,47-/m0/s1. InChi Key: LLPWNQMSUYAGQI-OOSPGMBYSA-N. Origin: Plant/Panax notoginseng.