Noscapine (hydrochloride)

Noscapine is an alkaloid that has been found in opium and has anticancer and antitussive properties. It binds to tubulin and induces cell cycle arrest at the G2/M phase in HeLa cells when used at a concentration of 20 µM. Noscapine induces apoptosis in HeLa cells and thymocytes (IC50s = 25 and 10 µM, respectively) and reduces proliferation of MCF-7 breast and Renal 1983 bladder cancer cells (IC50s = 42.3 and 39.1 µM, respectively). In vivo, noscapine (120 mg/kg) induces tumor regression in an MCF-7 mouse xenograft model. Noscapine (30 and 70 mg/kg) decreases the number of citric acid-induced coughs in guinea pigs.Formal Name: (3S)-6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranone, monohydrochloride. CAS Number: 912-60-7. Synonyms: Narcotine, Opianine. Molecular Formula: C22H23NO7 . HCl. Formula Weight: 449.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/m, DMSO: 30 mg/m, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 214, 313 nm. SMILES: COC1=C2C(CCN(C)[C@@]2([H])[C@]3([H])C(C=CC(OC)=C4OC)=C4C(O3)=O)=CC5=C1OCO5.Cl. InChi Code: InChI=1S/C22H23NO7.ClH/c1-23-8-7-11-9-14-20(29-10-28-14)21(27-4)15(11)17(23)18-12-5-6-13(25-2)19(26-3)16(12)22(24)30-18,/h5-6,9,17-18H,7-8,10H2,1-4H3,1H/t17-,18+,/m1./s1. InChi Key: MFLVZFXCSKVCSH-URBRKQAFSA-N.