nor-NOHA acetate

Description: nor-NOHA acetate (Nomega-Hydroxy-nor-L-arginine acetate) is a reversible inhibitor of arginase with anti-leukemic activity, effective in treating endothelial dysfunction, immunosuppression, and metabolism regulation. Target: Arginase, Apoptosis. Smiles: O=C(O)[C@@H](N)CCNC(NO)=N.CC(O)=O.CC(O)=O. References: Ng KP, et al. The arginase inhibitor Nomega-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11,13(10):e0205254.