Nogalamycin

Nogalamycin is an anthracycline originally isolated from S. nogalater and a DNA-intercalating agent. It inhibits the DNA-unwinding and ATPase activities of P. falciparum DNA helicase 60 (IC50s = 2 and 0.5 µM, respectively) and the DNA cleavage activity of vaccinia virus topoisomerase (IC50 = 0.7 µM). Nogalamycin also inhibits the growth of MCF-7 and MDA-MB-231 human breast cancer cells (IC50s = 0.242 and 0.37 µM, respectively).Formal Name: (2R,3S,4R,5R,6R,11S,13S,14R)-11-[(6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy]-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-2,6-epoxy-2H-naphthaceno[1,2-b]oxocin-14-carboxylic acid, methyl ester. CAS Number: 1404-15-5. Synonyms: NSC 70845, U 15167. Molecular Formula: C39H49NO16. Formula Weight: 787.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: soluble, Methanol: Soluble. SMILES: OC1=C(C(C(C(O)=CC2=C3O[C@@]4([H])[C@@H](O)[C@H](N(C)C)[C@@H](O)[C@@]2(O4)C)=C3C5=O)=O)C5=CC6=C1[C@@H](O[C@@]7([H])[C@H](OC)[C@@](OC)(C)[C@@H](OC)[C@H](C)O7)C[C@](C)(O)[C@@H]6C(OC)=O. InChi Code: InChI=1S/C39H49NO16/c1-14-32(49-7)39(4,52-10)33(50-8)36(53-14)54-19-13-37(2,48)24(34(47)51-9)15-11-16-21(27(43)20(15)19)28(44)22-18(41)12-17-30(23(22)26(16)42)55-35-29(45)25(40(5)6)31(46)38(17,3)56-35/h11-12,14,19,24-25,29,31-33,35-36,41,43,45-46,48H,13H2,1-10H3/t14-,19-,24-,25-,29-,31+,32-,33-,35+,36-,37-,38+,39+/m0/s1. InChi Key: KGTDRFCXGRULNK-JYOBTZKQSA-N. Origin: Bacterium/Streptomyces sp..