Nitazoxanide

Nitazoxanide
COVID-19 Research
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay13692-10 10 mg -

6 - 10 business days*

66.00€
Cay13692-50 50 mg -

6 - 10 business days*

290.00€
Cay13692-100 100 mg -

6 - 10 business days*

509.00€
Cay13692-250 250 mg -

6 - 10 business days*

1,111.00€
 
Nitazoxanide is a prodrug form of the antiparasitic tizoxanide (Cay-13693), an inhibitor of... more
Product information "Nitazoxanide"
Nitazoxanide is a prodrug form of the antiparasitic tizoxanide (Cay-13693), an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR). It inhibits growth of the parasite C. parvum in MDBK cells when used at a concentration of 10 µg/ml. It is active against M. tuberculosis and M. bovis (MIC = 16 µg/ml for both) and bactericidal against replicating and non-replicating M. tuberculosis. Nitazoxanide (5 and 10 µM) inhibits replication of severe acute respiratory coronavirus 2 (SARS-CoV-2) and Middle East respiratory syndrome CoV (MERS-CoV). It also inhibits viral hemagglutinin N-glycosylation and replication of the influenza strains H1N1 PR8 and WSN, as well as H5N9 A/Ck viruses (EC50s = 1, 0.5, and 1 µg/ml, respectively). Nitazoxanide (250 mg/kg) reduces oocyst shedding and parasite burden, but not the severity of diarrhea, in a gnotobiotic piglet model of C. parvum infection. Formulations containing nitazoxanide have been used in the treatment of diarrhea caused by G. lamblia or C. parvum.Formal Name: 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-benzamide. CAS Number: 55981-09-4. Synonyms: NSC 697855, NTZ. Molecular Formula: C12H9N3O5S. Formula Weight: 307.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml. lambdamax: 238, 341 nm. SMILES: O=C(NC1=NC=C([N+]([O-])=O)S1)C2=C(OC(C)=O)C=CC=C2. InChi Code: InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17). InChi Key: YQNQNVDNTFHQSW-UHFFFAOYSA-N.
Keywords: NSC 697855, NTZ, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-benzamide
Supplier: Cayman Chemical
Supplier-Nr: 13692

Properties

Application: Pyruvate-ferredoxin oxidoreductase inhibitor
MW: 307.3 D
Formula: C12H9N3O5S
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 55981-09-4| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335, H402
P Phrases: P261, P264, P270, P271, P273, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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COVID-19 Research
Nitazoxanide Nitazoxanide
44.00€ * From 39.60€ *
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