Nisoxetine (hydrochloride)

Nisoxetine is a norepinephrine transporter (NET) inhibitor (Ki = 5.1 nM). It is selective for NET over the dopamine transporter (DAT) and the serotonin (5-HT) transporter (SERT, Kis = 477 and 383 nM, respectively). Nisoxetine inhibits norepinephrine uptake and inhibits amphetamine-induced increases in norepinephrine release in mouse brain (EC50s = 2.97 and 0.08 µM, respectively). It reduces increases in locomotor activity induced by d-N-ethylamphetamine, methylphenidate, and cocaine, but not morphine, in mice when administered at a dose of 32 mg/kg. Nisoxetine (0.5 mg/kg i.v.) also reduces cataplexy in narcoleptic dogs.Formal Name: gamma-(2-methoxyphenoxy)-N-methyl-benzenepropanamine, monohydrochloride. CAS Number: 57754-86-6. Synonyms: Lilly 94939, NSC 298819. Molecular Formula: C17H21NO2 . HCl. Formula Weight: 307.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: 50 mg/ml, Water: 20 mg/ml. SMILES: CNCCC(C1=CC=CC=C1)OC2=C(OC)C=CC=C2.Cl. InChi Code: InChI=1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2,/h3-11,15,18H,12-13H2,1-2H3,1H. InChi Key: LCEURBZEQJZUPV-UHFFFAOYSA-N.