Nipecotic Acid

Nipecotic acid is an inhibitor of GABA transporters (GAT, IC50s = 2.6, 310, 29, and 16 µM for mouse GAT-1, GAT-2, GAT-3, and GAT-4, respectively). It does not bind GABAA or GABAB receptors (IC50s = >100 µM for both) but does bind the adenosine A3 receptor (IC50 = 0.01 µM). Nipecotic acid inhibits GABA uptake in isolated rabbit choroid plexus (IC50 = 244 µM). It inhibits lactate dehydrogenase (LDH) release (EC50 = ~5 µM) and aggregation of a mutant form of huntingtin, htt-N63-148Q, in PC12 cells. Intraventricular administration of nipecotic acid (300 µg/animal) decreases tail flick reaction time in a rat model of morphine-induced analgesia.Formal Name: 3-piperidinecarboxylic acid. CAS Number: 498-95-3. Synonyms: (±)-Nipecotic Acid, (R,S)-Nipecotic Acid, 3-Piperidine Carboxylic Acid, DL-Piperidine 3-Carboxylic Acid. Molecular Formula: C6H11NO2. Formula Weight: 129.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: Slightly soluble, DMSO: Slightly soluble, Ethanol: Slightly soluble, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(C1CCCNC1)O. InChi Code: InChI=1S/C6H11NO2/c8-6(9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H,8,9). InChi Key: XJLSEXAGTJCILF-UHFFFAOYSA-N.