Nimbin

Nimbin is a limonoid that has been found in neem seeds and has diverse biological activities. It inhibits the growth of the plant pathogenic fungus D. oryzae by 64.8% when used at a concentration of 1,000 ppm. Nimbin (0.02-2,000 µM) has antifeedant activity against S. littoralis in a choice test. It decreases melanin content to 20.9% of control, without affecting viability, in B16 murine melanoma cells when used at a concentration of 25 µg/ml. Nimbin inhibits activation of Epstein-Barr virus early antigen (EBV-EA) induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014) in Raji cells (IC50 = 499 mol ratio/32 pmol TPA).Formal Name: (2R,3aR,4aS,5R,5aR,6R,9aR,10S,10aR)-5-(acetyloxy)-2-(3-furanyl)-3,3a,4a,5,5a,6,9,9a,10,10a-decahydro-6-(methoxycarbonyl)-1,6,9a,10a-tetramethyl-9-oxo-2H-cyclopenta[b]naphtho[2,3-d]furan-10-acetic acid, methyl ester. CAS Number: 5945-86-8. Molecular Formula: C30H36O9. Formula Weight: 540.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: slightly soluble, Ethyl Acetate: slightly soluble. SMILES: CC1=C2[C@@]3(C)[C@H](CC(OC)=O)[C@@]4(C)C(C=C[C@](C(OC)=O)(C)[C@]4([H])[C@@H](OC(C)=O)[C@@]3([H])O[C@]2([H])C[C@@]1([H])C5=COC=C5)=O. InChi Code: InChI=1S/C30H36O9/c1-15-18(17-9-11-37-14-17)12-19-23(15)30(5)20(13-22(33)35-6)29(4)21(32)8-10-28(3,27(34)36-7)25(29)24(26(30)39-19)38-16(2)31/h8-11,14,18-20,24-26H,12-13H2,1-7H3/t18-,19-,20-,24-,25+,26-,28-,29+,30-/m1/s1. InChi Key: NHOIBRJOQAYBJT-IMGVWCFESA-N. Origin: Synthetic.