NH125

NH125 is an imidazole that has potent antibacterial properties in drug-resistant bacteria. In bacteria, NH125 inhibits several histidine kinases, inhibiting YycG with an IC50 of 6.6 µM. NH125 also decreases the viability of several cancer cell lines with IC50 values ranging from 0.7-4.7 µM. In mammalian cells, NH125 strongly inhibits eEF-2K (IC50 = 60 nM), with weaker effects on protein kinase C (IC50 = 7.5 µM), protein kinase A (IC50 = 80 µM), and calmodulin-dependent kinase II (IC50 = 100 µM).Formal Name: 1-hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazolium-iodide. CAS Number: 278603-08-0. Molecular Formula: C27H45IN2. Formula Weight: 524.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml, DMSO: 2.5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 214 nm. SMILES: c1cccc(c1)Cn1cc[n+](c1C)CCCCCCCCCCCCCCCC.[I-]. InChi Code: InChI=1S/C27H45N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-28-23-24-29(26(28)2)25-27-20-17-16-18-21-27,/h16-18,20-21,23-24H,3-15,19,22,25H2,1-2H3,1H/q+1,/p-1. InChi Key: RVWOHCBHAGBLLT-UHFFFAOYSA-M.