Nelarabine

Nelarabine is a purine nucleoside analog that is used as a cytotoxic agent in hematological malignancies. Nelarabine is converted into arabinosyl-guanine (ara-G) in the blood, and ara-G is selectively accumulated in T cells and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into DNA. This leads to DNA breaks, increased expression of Fas ligand, and apoptosis. Ara-G is accumulated most effectively by acute lymphoid leukemia and chronic myeloid leukemia blasts.Formal Name: 9-beta-D-arabinofuranosyl-6-methoxy-9H-purin-2-amine. CAS Number: 121032-29-9. Synonyms: GW 506U78, Nelzarabine. Molecular Formula: C11H15N5O5. Formula Weight: 297.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 211, 247, 281 nm. SMILES: OC[C@@H]1[C@@H](O)[C@H](O)[C@H](N2C=NC3=C2N=C(N)N=C3OC)O1. InChi Code: InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1. InChi Key: IXOXBSCIXZEQEQ-UHTZMRCNSA-N.