NCH-51

NCH-51 is an inhibitor of histone deacetylases (HDACs) with IC50 values of 48, 32, and 41 nM for HDAC1, 4, and 6, respectively. It increases acetylation of histone H4 and alpha-tubulin in HCT116 cells when used at concentrations ranging from 1 to 25 µM and inhibits the growth of a variety of cancer cell lines (EC50s = 1.1-9.1 µM). NCH-51 (0.4-1.6 µM) also induces HIV-1 viral replication in OM10.1 and ACH-2 cells latently infected with HIV-1 when used alone and, to a greater effect, when used in the presence of TNF-alpha, with cytotoxic concentration (CC50) values of approximately 2 µM for both cell lines.Formal Name: S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester, 2-methyl-propanethioic acid. CAS Number: 848354-66-5. Synonyms: PTACH. Molecular Formula: C20H26N2O2S2. Formula Weight: 390.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 10 mg/ml. lambdamax: 233, 269 nm. SMILES: CC(C)C(SCCCCCCC(NC1=NC(C2=CC=CC=C2)=CS1)=O)=O. InChi Code: InChI=1S/C20H26N2O2S2/c1-15(2)19(24)25-13-9-4-3-8-12-18(23)22-20-21-17(14-26-20)16-10-6-5-7-11-16/h5-7,10-11,14-15H,3-4,8-9,12-13H2,1-2H3,(H,21,22,23). InChi Key: MDYDGUOQFUQOGE-UHFFFAOYSA-N.