Nanaomycin A

Nanaomycin A is a quinone bacterial metabolite originally isolated from Streptomyces that has antimicrobial activity. It inhibits the growth of a variety of bacteria (MICs = P. falciparum (IC80 = 0.033 µM). Nanaomycin A is a selective DNA methyltransferase 3B (DNMT3B) inhibitor that inhibits proliferation of HCT116, A549, and HL-60 cancer cells (IC50s = 0.4, 4.1, and 0.8 µM, respectively). Nanaomycin A promotes the differentiation of human induced pluripotent stem (iPS) cells into hepatoblasts at the definitive endoderm cell-to-hepatoblast stage, but not the iPS cell-to-definitive endoderm cell stage, when used at a concentration of 1 µM.Formal Name: (1S,3R)-3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic acid. CAS Number: 52934-83-5. Synonyms: Antibiotic OS 3966A, Nanafrocin, NNM-A, NSC 267461. Molecular Formula: C16H14O6. Formula Weight: 302.3. Purity: >80%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10 mg/ml. SMILES: O=C1C2=C([C@@H](O[C@H](C2)CC(O)=O)C)C(C3=C(O)C=CC=C31)=O. InChi Code: InChI=1S/C16H14O6/c1-7-13-10(5-8(22-7)6-12(18)19)15(20)9-3-2-4-11(17)14(9)16(13)21/h2-4,7-8,17H,5-6H2,1H3,(H,18,19)/t7-,8+/m0/s1. InChi Key: ZCJHPTKRISJQTN-JGVFFNPUSA-N. Origin: Synthetic.