N6022

N6022 is a tight-binding, specific, and fully reversible inhibitor of S-nitrosoglutathione reductase (GSNOR, IC50 = 8 nM, Ki = 2.5 nM). It is reported to bind in the GSNO substrate binding pocket like a competitive inhibitor, although in kinetic assays it behaves with a mixed uncompetitive mode of inhibition toward the GSNO substrate and a mixed competitive mode of inhibition toward the formaldehyde adduct, S-hydroxymethylglutathione.Formal Name: 1-[4-(aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid. CAS Number: 1208315-24-5. Molecular Formula: C24H22N4O3. Formula Weight: 414.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, Ethanol: 1 mg/mL, PBS (pH 7.2): 0.1 mg/mL. lambdamax: 304 nm. SMILES: NC(C(C=C1)=CC(C)=C1N2C(CCC(O)=O)=CC=C2C3=CC=C(N4C=NC=C4)C=C3)=O. InChi Code: InChI=1S/C24H22N4O3/c1-16-14-18(24(25)31)4-9-21(16)28-20(8-11-23(29)30)7-10-22(28)17-2-5-19(6-3-17)27-13-12-26-15-27/h2-7,9-10,12-15H,8,11H2,1H3,(H2,25,31)(H,29,30). InChi Key: YVPGZQLRPAGKLA-UHFFFAOYSA-N.