N1,N12-Diacetylspermine (hydrochloride)

N1,N12-Acetylspermine is a diacetylated derivative of spermine (Cay-18041), an endogenous polyamine synthesized from spermidine (Cay-14918), that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes. Upregulation of N1,N12-acetylspermine has been linked to the incidence of cancer, making this natural polyamine a potential biomarker for cancer detection.Formal Name: N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis-acetamide, dihydrochloride. CAS Number: 77928-71-3. Synonyms: BAS. Molecular Formula: C14H30N4O2 . 2HCl. Formula Weight: 359.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.2 mg/mL, PBS (pH 7.2): 10 mg/ml. SMILES: CC(NCCCNCCCCNCCCNC(C)=O)=O.Cl.Cl. InChi Code: InChI=1S/C14H30N4O2.2ClH/c1-13(19)17-11-5-9-15-7-3-4-8-16-10-6-12-18-14(2)20,,/h15-16H,3-12H2,1-2H3,(H,17,19)(H,18,20),2*1H. InChi Key: NQNXERHVLXYXRO-UHFFFAOYSA-N.