N-Vanillylnonanamide

White to off-white powder. Soluble in DMSO (10mg/ml), DMF (10mg/ml), ethanol (30mg/ml) or methanol (100mg/ml). Chemical. CAS: 2444-46-4. Formula: C17H27NO3. MW: 293.41. Nonivamide is a transient receptor potential vanilloid type 1 (TRPV1) agonist and an analog of capsaicin, with anti-inflammatory, antiobesity and antifouling properties. Nonivamide has anti-inflammatory potential by inhibiting LPS-induced activation of the MAPK pathway. Nonivamide enhanced hyperthermia-induced apoptosis via a mitochondrial-caspase dependent pathway, and might be useful as cancer treatment enhancer. Nonivamide has also shown to be effective antiobesity agent by reducing energy intake, enhancing energy metabolism, decreasing serum triacylglycerol content and inhibiting adipogenesis via activation of the transient receptor potential cation channel subfamily V member 1 (TRPV1). Formulations containing nonivamide have been used in pepper spray weaponry for riot control.