N-trans-Feruloyltyramine

N-trans-Feruloyltyramine is a phenolic amide originally isolated from S. melongena that has diverse biological activities, including anti-inflammatory, antioxidative, and antiproliferative properties. It decreases nitric oxide (NO) production (IC50 = 17.36 µM) and inducible NO synthase (iNOS) activity and increases NO scavenging without inducing cytotoxicity in LPS-stimulated BV-2 cells. It also scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals in TLC autographic and spectrophotometric assays. N-trans-Feruloyltyramine inhibits proliferation of HeLa and L929 cells by 72.2 and 22%, respectively, when used at a concentration of 30 µg/ml.Formal Name: (2E)-3-(4-hydroxy-3-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-propenamide. CAS Number: 66648-43-9. Synonyms: Alfrutamide, (E)-Feruloyltyramine, Moupinamide. Molecular Formula: C18H19NO4. Formula Weight: 313.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.33 mg/ml, Ethanol: 25 mg/ml. lambdamax: 221, 294, 320 nm. SMILES: OC1=CC=C(CCNC(/C=C/C2=CC(OC)=C(O)C=C2)=O)C=C1. InChi Code: InChI=1S/C18H19NO4/c1-23-17-12-14(4-8-16(17)21)5-9-18(22)19-11-10-13-2-6-15(20)7-3-13/h2-9,12,20-21H,10-11H2,1H3,(H,19,22)/b9-5+. InChi Key: NPNNKDMSXVRADT-WEVVVXLNSA-N. Origin: Plant/Aristolochia debilis.