N-Carbamyl-L-Glutamic Acid

N-Carbamyl-L-glutamic acid is an activator of carbamoyl phosphate synthetase 1 (CPS1), the first enzyme in the urea cycle. It is a structural analog of N-acetyl-glutamate, an endogenous CPS1 activator. N-Carbamyl-L-glutamic acid (500 mg/kg) reduces 2-ketoisocaproate-induced hyperammonemia in a mouse model of 3-hydroxy-3-methylglutaryl-CoA lyase deficiency. It inhibits cell proliferation of a variety of cancer cell lines with IC50 values ranging from 5 to 7.5 nM. It also inhibits tumor growth by 80 and 82% in orthotopic mouse models of pancreatic and triple-negative breast cancer, respectively, when administered at a dose of 120 mg/kg per day for 10 days. Formulations containing N-carbamyl-L-glutamic acid have been used in the treatment of primary N-acetyl-glutamate synthase deficiency.Formal Name: N-(aminocarbonyl)-L-glutamic acid. CAS Number: 1188-38-1. Synonyms: Carglumic Acid. Molecular Formula: C6H10N2O5. Formula Weight: 190.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: OC(CC[C@H](NC(N)=O)C(O)=O)=O. InChi Code: InChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1. InChi Key: LCQLHJZYVOQKHU-VKHMYHEASA-N.