N-acetyl-L-Cysteine

N-Acetyl-L-cysteine (NAC) is an antioxidant and precursor of glutathione that has multiple effects in cells and animals. As an antioxidant, NAC scavenges hydrogen peroxide, hydroxyl radical, and hypochlorous acid. NAC may be deacetylated to cysteine, which can be combined with glutamate and glycine to produce reduced glutathione (Cay-10007461), which serves to reduce hydroperoxides and detoxify xenobiotics. The free sulfhydryl group of NAC can also hydrolyze disulfide bonds of mucins and other proteins, thus facilitating clearance of mucus. Through these actions, NAC inhibits DNA adduct formation, limits hepatotoxic effects of acetaminophen, and provides diverse cytoprotective effects in vivo.Formal Name: N-acetyl-L-cysteine. CAS Number: 616-91-1. Synonyms: Acetylcysteine, NSC 111180, NAC. Molecular Formula: C5H9NO3S. Formula Weight: 163.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/mL, DMSO: 50 mg/mL, Ethanol: 50 mg/mL, PBS (pH 7.2): 30 mg/mL. SMILES: SC[C@H](NC(C)=O)C(O)=O. InChi Code: InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1. InChi Key: PWKSKIMOESPYIA-BYPYZUCNSA-N.