Mycro 3

Mycro 3 is an inhibitor of the protein-protein interaction between c-Myc and c-Myc associated protein (Max, IC50 = 40 µM). It is also an inhibitor of Max dimerization (IC50 = 88 µM). Mycro 3 selectively reduces the viability of c-Myc-expressing TGR-1 fibroblasts over c-Myc-null HO15.19 fibroblasts (IC50s = 0.25 and 9 µM, respectively). It decreases tumor weight in PANC-1 and MIA PaCa-2 pancreatic cancer mouse xenograft models when administered at a dose of 100 mg/kg per day. Mycro 3 (5 mg/kg every three days), in combination with docetaxel (Cay-11637) or abiraterone (Cay-9002768), reduces tumor volume and improves survival in an LNCaP prostate cancer mouse xenograft model.Formal Name: 5-[[[7-(chlorodifluoromethyl)-5-(2-furanyl)pyrazolo[1,5-a]pyrimidin-2-yl]carbonyl]amino]-1-phenyl-1H-pyrazole-4-carboxylic acid, ethyl ester. CAS Number: 944547-46-0. Molecular Formula: C24H17ClF2N6O4. Formula Weight: 526.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: O=C(C1=C(NC(C2=NN3C(N=C(C4=CC=CO4)C=C3C(F)(Cl)F)=C2)=O)N(C5=CC=CC=C5)N=C1)OCC. InChi Code: InChI=1S/C24H17ClF2N6O4/c1-2-36-23(35)15-13-28-32(14-7-4-3-5-8-14)21(15)30-22(34)17-12-20-29-16(18-9-6-10-37-18)11-19(24(25,26)27)33(20)31-17/h3-13H,2H2,1H3,(H,30,34). InChi Key: YPPNLSKYXDXQGD-UHFFFAOYSA-N.