MYCi975

MYCi975 is an inhibitor of the protein-protein interaction between Myc and Myc-associated factor X (MAX). It binds to Myc (Kd = 2.75 µM) and increases GSK3beta-mediated Myc phosphorylation in a cell-free assay. MYCi975 (5 and 10 µM) decreases the viability of MyC-CaP and LNCaP prostate cancer cells. It induces apoptosis in a panel of 11 breast cancer cell lines when used at a concentration of 10 µM. In vivo, MYCi975 (100 mg/kg) reduces tumor volume in a MyC-CaP mouse xenograft model.Formal Name: 4'-chloro-6-[(4-chlorophenyl)methoxy]-3-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3'-(trifluoromethyl)-[1,1'-biphenyl]-2-ol. CAS Number: 2289691-01-4. Synonyms: NUCC-0200975. Molecular Formula: C25H16Cl2F6N2O2. Formula Weight: 561.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Soluble, DMSO: Soluble. SMILES: ClC(C=C1)=CC=C1COC(C=CC(C2=CC(C(F)(F)F)=NN2C)=C3O)=C3C4=CC(C(F)(F)F)=C(Cl)C=C4. InChi Code: InChI=1S/C25H16Cl2F6N2O2/c1-35-19(11-21(34-35)25(31,32)33)16-7-9-20(37-12-13-2-5-15(26)6-3-13)22(23(16)36)14-4-8-18(27)17(10-14)24(28,29)30/h2-11,36H,12H2,1H3. InChi Key: VSDFDVBYONIJLD-UHFFFAOYSA-N.