MTOB (sodium salt)

MTOB is an intermediate in the methionine salvage pathway. It is also a substrate of the dehydrogenase domain of C-terminal-binding protein 1 (CtBP1) and CtBP2 that inhibits the transcriptional corepressor activity of CtBP1 and -2 at concentrations in the millimolar range. MTOB reduces cell viability in p53 wild-type and p53 knockout HCT116 colorectal cancer cells and induces apoptosis in p53 knockout HCT116 cells. It inhibits growth of MCF-7 breast cancer, MDA-MB-231 breast cancer, and U2OS osteosarcoma cells in a concentration-dependent manner. MTOB reduces tumor mass and ascites volume in a mouse xenograft model using HCT116 cells lacking p53 when administered at a dose of 750 mg/kg. It also reduces the neurological severity score (NSS) and the loss of righting reflex duration in a mouse model of traumatic brain injury.. SMILES: CSCCC(C([O-])=O)=O.[Na+]. InChi Code: InChI=1S/C5H8O3S.Na/c1-9-3-2-4(6)5(7)8,/h2-3H2,1H3,(H,7,8),/q,+1/p-1. InChi Key: IFSCKRWNXKWTLR-UHFFFAOYSA-M