MS 245 (oxalate)

MS 245 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 2.3 nM for the human recombinant receptor). It is selective for 5-HT6 over 5-HT2A and 5-HT2C receptors (Kis = 130 and 23 nM, respectively), as well as 5-HT1A, 5-HT1B, 5-HT1E, 5-HT3, and 5-HT7 receptors (Kis = 720, 9,200, 4,220, 2,390, and 600 nM, respectively). MS 245 decreases cAMP production induced by 5-HT in HEK293 cells expressing 5-HT6 (pA2 = 8.88 nM). It potentiates drug discrimination induced by (+)-amphetamine, but has no effect on cocaine or (-)-nicotine (Cay-20887) drug discrimination in rats when administered at a dose of 5 mg/kg.Formal Name: 5-methoxy-N,N-dimethyl-1-(phenylsulfonyl)-1H-indole-3-ethanamine, monoethanedioate. CAS Number: 275363-58-1. Molecular Formula: C19H22N2O3S . C2H2O4. Formula Weight: 448.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 212, 217, 259 nm. SMILES: COC1=CC=C(N(S(C2=CC=CC=C2)(=O)=O)C=C3CCN(C)C)C3=C1.OC(C(O)=O)=O. InChi Code: InChI=1S/C19H22N2O3S.C2H2O4/c1-20(2)12-11-15-14-21(19-10-9-16(24-3)13-18(15)19)25(22,23)17-7-5-4-6-8-17,3-1(4)2(5)6/h4-10,13-14H,11-12H2,1-3H3,(H,3,4)(H,5,6). InChi Key: BLSWAEGCRSFTJG-UHFFFAOYSA-N.