MRT67307
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents... more
Product information "MRT67307"
Description: Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-beta and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophages. MRT67307 is a kinase inhibitor that has been shown to inhibit TBK1, MARK1-4, IKKepsilon, and NUAK1 (IC50 values are 19, 27-52, 160, and 230 nM, respectively), the salt-inducible kinases (SIKs, IC50s =250, 67, and 430 nM for SIK1, SIK2, and SIK3, respectively) and ULK1 and ULK2 (IC50s = 45 and 38 nM, respectively). Target: Autophagy, IkappaB/IKK. Smiles: O=C(NCCCNc1nc(Nc2cccc(CN3CCOCC3)c2)ncc1C1CC1)C1CCC1. References: Clark K, et al. Biochem J. 2011, 434(1), 93-104.
| Keywords: | MRT67307 HCl |
| Supplier: | TargetMol |
| Supplier-Nr: | T0097 |
Properties
| MW: | 464.6 D |
| Formula: | C26H36N6O2 |
Database Information
| CAS : | 1190378-57-4| Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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