Mps1-IN-2

Mps1-IN-2 is an ATP-competitive inhibitor of the checkpoint kinase Mps1 (IC50 = 145 nM). It is 1,000-fold selective for Mps1 over a panel of 352 kinases at 10 µM, but does inhibit Plk1 (Kd = 61 nM).Formal Name: 9-cyclopentyl-2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,7,8,9-tetrahydro-5-methyl-6H-pyrimido[4,5-b][1,4]diazepin-6-one. CAS Number: 1228817-38-6. Molecular Formula: C26H36N6O3. Formula Weight: 480.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 1 mg/ml, Ethanol: slightly soluble. lambdamax: 288 nm. SMILES: OC1CCN(C2=CC(OCC)=C(NC3=NC=C(N(C)C(CCN4C5CCCC5)=O)C4=N3)C=C2)CC1. InChi Code: InChI=1S/C26H36N6O3/c1-3-35-23-16-19(31-13-10-20(33)11-14-31)8-9-21(23)28-26-27-17-22-25(29-26)32(18-6-4-5-7-18)15-12-24(34)30(22)2/h8-9,16-18,20,33H,3-7,10-15H2,1-2H3,(H,27,28,29). InChi Key: WELBJLUKWAJOQV-UHFFFAOYSA-N.